Identified neurofilament light chain (NfL) as the first biochemical marker of pre-symptomatic ALS.
Platform presentation at International Symposium on ALS/MND: “Blood and CSF Neurofilament Levels as Biomarkers of Pre-Symptomatic Disease”
We found that NfL is increased in both cerebrospinal fluid (CSF) and blood (serum) prior to the emergence of clinically manifest ALS.
The striking NfL signal in blood is critically important, because (contrary to CSF) blood-based monitoring is feasible and immediately relevant for practical use in clinical trials.
This work was done in collaboration with Dr. Andrea Malaspina, University College London, UK.