Publications & Talks

Cohen Y, Sinai I, Magen I, Danino YM, Wuu J, Malaspina A, Benatar M, Hornstein E. IsomiR utility in amyotrophic lateral sclerosis prognostication. Med. 2025 Nov 21:100928. Online ahead of print. [PubMed link: 41274292]

Wu G, Chen W, Wuu J, Jain A, Myers J, Cordts I, Rampersaud E, Heckmann JM, Nel M, Granit V, Statland J, Swenson A, Ravits J, McMillan CT, Elman L, Caress J, Burns TM, Pioro EP, Trivedi J, Katz J, Jackson C, Maiser S, Walk D, So Y, McCauley JL, Baker MC, Taylor JP, Zuchner S, Rademakers R, van Blitterswijk M, Benatar M. Shared burden of ultra-rare genetic variants across a spectrum of motor neuron diseases. Transl Neurodegener. 2025 Oct 29;14(1):54. [PubMed link: 41152957]

Crayle JI, Rampersaud E, Myers JR, Wuu J, Wu G, Benatar M, Bedlack RS. Author Response: Genetic Associations With an Amyotrophic Lateral Sclerosis Reversal Phenotype. Neurology. 2025 Nov 11;105(9):e210166. Epub 2025 Oct 3. [PubMed link: 41043093]

Trubshaw M, Gohil C, Edmond E, Proudfoot M, Yoganathan K, Wuu J, Northall A, Kohl O, Stagg CJ, Nobre AC, Talbot K, Thompson AG, Benatar M, Woolrich M, Turner MR. Divergent Brain Network Activity in Asymptomatic C9orf72 and SOD1 Variant Carriers Compared With Established Amyotrophic Lateral Sclerosis. Hum Brain Mapp. 2025 Oct 1;46(14):e70345. [PubMed link: 41042072]

Dergai O, Wuu J, Koziczak-Holbro M, Malaspina A, Granit V, Hernandez JP, Cooley A, Sachdev R, Yu L, Bidinosti M, Flotte L, Nash M, Jennings LL, Berry JD, Bruijn LI, Brachat S, Benatar M. Skeletal Muscle Biomarkers of Amyotrophic Lateral Sclerosis: A Large-Scale, Multi-Cohort Proteomic Study. Ann Neurol. 2025 Sep 29. Epub 2025 Sep 29. [PubMed link: 41020397]

Baumeister TR, Westeneng HJ, van den Berg L; Canadian ALS Neuroimaging Consortium (CALSNIC); Kalra S, Iturria-Medina Y. Multimodal Neuroimaging-Guided Stratification in Amyotrophic Lateral Sclerosis Reveals Three Disease Subtypes: A Multi-Cohort Analysis. Hum Brain Mapp. 2025 Oct 1;46(14):e70341. [PubMed link: 40990258]

Parnianpour P, Harrison M, Benatar M, Briemberg H, Dionne A, Dupré N, Frayne R, Genge A, Graham SJ, Korngut L, Seres P, Wilman A, Zinman L; Canadian ALS Neuroimaging Consortium (CALSNIC); Kalra S. Progressive and short-interval changes observed in the corticospinal tract and corpus callosum of ALS patients: A texture analysis study. AJNR Am J Neuroradiol. 2025 Sep 18:ajnr.A9013. Online ahead of print. [PubMed link: 40968018]

Sheth U, Harrison R, Ferber K, Rosenbaugh EG, Bevis A, Khillan R, Benatar M, Bjorklund NL, Di Daniel E, Harris GA, Kahn OI, Liu Y, Zetterberg H, Mitic LL, Graham D, Gendron TF. Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassays. Clin Chem Lab Med. 2025 Sep 8. Online ahead of print. [PubMed link: 40958756]

Laverde-Paz MJ, Maki K, Melo-Escobar I, McCartan R, Benatar M, Wuu J, Zeier Z. Generation and characterization of two pluripotent stem cell lines from Primary Lateral Sclerosis (PLS) patients. Stem Cell Res. 2025 Sep 8;88:103828. Epub 2025 Sep 8. [PubMed link: 40957373]

Tzeplaeff L, Galhoz A, Meijs C, Caldi Gomes L, Kovac A, Menzel A, Değirmenci H, Alaamel A, Kaya HC, Çelik AG, Dinçer S, Korucuk M, Karaüzüm SB, Bayraktar E, Çiftçi V, Bilge U, Koç F, Demleitner AF, Buchberger A, von Heynitz R, Gmeiner V, Knellwolf C, Mouzouri M, Wuu J, Başak AN, Andersen PM, Kohlmayer F, Ashton NJ, Kuban W, Lenz C, Rogers ML, Zilka N, Corcia P, Lerner Y, Weber M, Turcanova Koprusakova M, Uysal H, Benatar M, Menden MP, Lingor P. Identification of a presymptomatic and early disease signature for amyotrophic lateral sclerosis (ALS): protocol of the premodiALS study. Neurol Res Pract. 2025 Aug 19;7(1):56. [PubMed link: 40830802]

Benatar M, Staffaroni AM, Wuu J, McDermott MP, Quintana M, Swidler J, Andersen G, Huey ED, Turner MR, Macklin EA, Berry JD, McMillan CT, Gendron T, Onyike C, Rosen H, Heuer HW, Grignon AL, Dave KD, Balas C, Gleixner A, Satlin A, Dunn B, Dacks P, Boxer AL. Design considerations for C9orf72 disease prevention trials. Brain. 2025 Nov 4;148(11):3844-3855. Epub 2025 Aug 5. [PubMed link: 40794569]

Benatar M, Cai X, McDermott MP, Granit V, Grignon AL, Colato D, Fernandez MC, Li Y, McBane K, Mesa L, Stanislaw C, Andersen PM, Carberry N, Wuu J. Proposed research criteria for mild motor impairment as a prodromal syndrome in amyotrophic lateral sclerosis. Neurology. 2025 Aug 26;105(4):e213917. Epub 2025 Jul 28. [PubMed link: 40720712]

Scirocco E, Allen MD, Giacomelli E, Ajroud-Driss S, Andrews J, Banack S, Bede P, Benatar M, Cheung K, Corcia P, de Carvalho M, Elman L, Fink JK, Genge A, Hardiman O, Harms M, Heitzman D, Jang G, Kano O, Kiernan MC, Lee I, Ludolph A, Mehta P, Ozdinler H, Rezania K, Schito P, Sherman AV, Silani V, Sorenson E, Turner MR, Van Den Berg L, Mitsumoto H, Paganoni S. Toward therapeutic trials in primary lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2025 Nov;26(7-8):623-630. Epub 2025 Jul 6. [PubMed link: 40618376]

O'Brien D, Alhathli E, Harwood C, Bhattacharya D, Gupta K, Julian T, Weinreich M, West RJH, Wang D, Byrne RP, McLaughlin RL, Wuu J, Benatar M, Cooper-Knock J, Shaw PJ. Extreme exercise in males is linked to mTOR signalling and onset of amyotrophic lateral sclerosis. Brain. 2025 Oct 3;148(10):3652-3664. Epub 2025 Jun 18. [PubMed link: 40577240]

Benatar M, McDermott MP. Examining the evidence for IL-2 in amyotrophic lateral sclerosis. Lancet. 2025 May 24;405(10492):1793-1795. [PubMed link: 40354800]