Manuscript emanating from the First International Pre-Symptomatic ALS Workshop

Highlights key lessons for ALS from studies in pre-symptomatic AD, PD, HD, FTD, and SMA.

Defines mild motor impairment (MMI), mild cognitive impairment (MCI), and mild behavioral impairment (MBI) as prodromal stages in ALS.

Presents a roadmap to ALS early intervention, and perhaps even disease prevention.