Adaptive platform trials to transform amyotrophic lateral sclerosis therapy development.

Paganoni S, Berry JD, Quintana M, Macklin E, Saville BR, Detry MA, Chase M, Sherman AV, Yu H, Drake K, Andrews J, Shefner J, Chibnik LB, Vestrucci M, Cudkowicz ME; Healey ALS Platform Trial Study Group.  Adaptive platform trials to transform amyotrophic lateral sclerosis therapy development.  Ann Neurol. 2022 Feb;91(2):165-175.  Epub 2022 Jan 10. [PubMed Link]