Extreme exercise in males is linked to mTOR signalling and onset of amyotrophic lateral sclerosis.

Dec 19, 2025

O’Brien D, Alhathli E, Harwood C, Bhattacharya D, Gupta K, Julian T, Weinreich M, West RJH, Wang D, Byrne RP, McLaughlin RL, Wuu J, Benatar M, Cooper-Knock J, Shaw PJ. Extreme exercise in males is linked to mTOR signalling and onset of amyotrophic lateral sclerosis. Brain. 2025 Oct 3;148(10):3652-3664. Epub 2025 Jun 18. [PubMed link]