Research Studies

Study Title

CALSNIC-2 (Canadian ALS Neuroimaging Consortium Study)

Enrollment Status

Active-Not Recruiting

Principal Investigators

PI: Sanjay Kalra, MD, PhD (University of Alberta)Site-PI: Michael Benatar, MD, PhD

Study Type

Observational

Goals

Investigate, in a multi-center fashion, the usefulness of advancing magnetic resonance imaging (MRI) techniques as potential biomarkers for ALS.

Enrolling

ALS patients, Controls

Eligibility

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Affected: Individuals affected with ALS or a related neurodegenerative disorder, including ALS-FTD, PLS, and PMA.
Controls: Healthy controls 40-80 years old.

Study Involvement

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3 half-day study visits at UMiami over an 8-month period

  • Brief family and medical history review
  • MRI Scan
  • Neuropsychological testing
  • Speech Testing
  • Neurological Exam (Affected Participants only)
  • Breathing Testing (Affected Participants only)

Primary Funding Source

ALS Canada

Related Publications

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Bharti K, J Graham S, Benatar M, Briemberg H, Chenji S, Dupré N, Dionne A, Frayne R, Genge A, Korngut L, Luk C, Zinman L, Kalra S; Canadian ALS Neuroimaging Consortium (CALSNIC). Functional alterations in large-scale resting-state networks of amyotrophic lateral sclerosis: A multi-site study across Canada and the United States. PLoS One. 2022 Jun 16;17(6):e0269154.

https://pubmed.ncbi.nlm.nih.gov/35709100

Related Presentations & Lectures

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McMillan CT (presenter), Wuu J, Hennessy L, Placek K, Clinical Research in ALS (CRiALS) Study, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, Canadian ALS Neuroimaging Consortium (CALSNIC), Quinn C, Elman L, Grossman M, Rampersaud E, Wu G, Taylor JP, Kalra S, Benatar M. Frequency, hazard, and genetic risk factors of cognitive impairment in amyotrophic lateral sclerosis (ALS). Invited presentation at the International Neuropsychological Society Annual Meeting (virtual), Feb 2-5, 2021.