Research Studies
Study Title
Lost in translation: Treatment Trials in the SOD1 Mouse and in Human ALS
Enrollment Status
Completed
Principal Investigators
Michael Benatar, MD, PhD
Study Type
Goals
Enrolling
Eligibility
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Study Involvement
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Contact
Links
Primary Funding Source
Related Publications
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Benatar M, Wuu J, Andersen PM, Atassi N, David W, Cudkowicz M, Schoenfeld D. Randomized, double-blind, placebo-controlled trial of arimoclomol in rapidly progressive SOD1 ALS. Neurology. 2018 Feb 13;90(7):e565-e574. Epub 2018 Jan 24.
https://pubmed.ncbi.nlm.nih.gov/29367439
Schnabel J. Neuroscience: Standard model. Nature. 2008 Aug 7;454(7205):682-5.
https://pubmed.ncbi.nlm.nih.gov/18685674
Benatar M. Lost in translation: treatment trials in the SOD1 mouse and in human ALS. Neurobiol Dis. 2007 Apr;26(1):1-13. Epub 2007 Jan 3.
Related Presentations & Lectures
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Benatar M (presenter), Wuu J, Atassi N, Cudkowicz M, Schoenfeld D. Randomized, phase II trial of arimoclomol in rapidly progressive SOD1 ALS. Late-breaking session platform presentation at the 27th International Symposium on ALS/MND, Dublin, Ireland, Dec 7-9, 2016.
Benatar M (invited speaker). ALS Therapy Development: Challenges and Opportunities. Platform presentation at the International Conference on Neuromuscular Disease. Toronto, Canada, July 2016.
Benatar M (invited speaker). Lessons for Charcot-Marie Tooth (CMT) Clinical Trials from ALS Experience. Inherited Neuropathic Consortium Annual Meeting. Miami, FL, January 2016.
Benatar M (invited speaker). Challenges and Opportunities in ALS Therapy Development. Ottawa International Conference on Neuromuscular Biology, Disease and Therapy. Ottawa, Canada, September 2015.
Benatar M (invited speaker). Challenges and Opportunities in ALS Therapy Development. Flinders University Center for Neuroscience Seminar. Adelaide, Australia, September 2015.
Benatar M (invited speaker). Challenges and Opportunities in ALS Therapy Development. Congress on Motor and Cognitive Degenerative Diseases. Yachay, Ecuador, January 2015.
Benatar M (invited speaker). ALS Therapy Development: Challenges and Opportunities. ALS Association Wisconsin Chapter. Milwaukee, WI, May 2014.
Benatar M (invited speaker). Pre-fALS: Pre-Symptomatic Studies in ALS. Workshop on Biomarker Studies in Pre-Symptomatic Carriers of Familial ALS/FTD. University of Oxford, Oxford, UK, January 2012.
Benatar M (invited speaker). Piecing Together the Puzzle of ALS: An Emerging Picture. Beijing International Conference on Neurology. Beijing, China, June 2012.
Benatar M (invited speaker). Animal Models in ALS: The Good, the Bad and the Ugly. Muscle Study Group Annual Meeting. Beaver Hollow, NY, September 2011.
Benatar M (invited speaker). Tackling the Challenges of ALS: A Familial Perspective. 2009 William L. Halseth ALS Visiting Lectureship. University of Colorado School of Medicine, Aurora, CO, February 2010.
Benatar M (invited speaker). Methodological Issues in Animal Therapeutic Studies: Lessons from Other Neurological Diseases. NINDS Meeting on Disease Modification and Anti-Epileptogenesis. Bethesda, MD, August 2010.
Benatar M (invited speaker). The Limitations of Animal Models of Neurodegenerative Disease. TREAT-NMD/NIH International Conference: Bottlenecks in Translational Medicine in Inherited Neuromuscular Diseases. Brussels, Belgium, November 2009.
Benatar M (invited speaker). Panel discussant on the topic of Animal Models for Neurological Disease: Success or Lack of Success for Translation. NINDS Training and Implementation Retreat. Airlie House, Warrenton, VA, March 2009.
Benatar M (invited speaker). Lessons for Huntington’s Disease from Amyotrophic Lateral Sclerosis. World Huntington’s Conference. Vancouver, Canada, September 2009.
Benatar M (invited speaker). Piecing Together the Puzzle of ALS: An Emerging Picture. Visiting Professor and Guest Lecturer, South African Neurological Association Meeting. Johannesburg, South Africa, March 2009.
Benatar M (invited speaker). Predictive, Preventive and Therapeutic Studies in Familial ALS. ALS Association Annual Leadership Forum. Orange County, CA, January 2008.