Research Studies

Study Title

SOD1 Arimoclomol Trial (Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial ALS)

Enrollment Status

Completed

Principal Investigators

Michael Benatar, MD, PhD

Study Type

Drug Trial

Goals

Demonstrate the safety, tolerability, and efficacy of arimoclomol in subjects with fast-progressing SOD1 ALS.

Enrolling

SOD1 ALS patients

Eligibility

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Study Involvement

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Contact

Links

Primary Funding Source

FDA, ALS Association

Related Publications

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Benatar M, Wuu J, Andersen PM, Atassi N, David W, Cudkowicz M, Schoenfeld D. Randomized, double-blind, placebo-controlled trial of arimoclomol in rapidly progressive SOD1 ALS. Neurology. 2018 Feb 13;90(7):e565-e574. Epub 2018 Jan 24.

https://pubmed.ncbi.nlm.nih.gov/29367439

Related Presentations & Lectures

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Benatar M (presenter), Wuu J, Atassi N, Cudkowicz M, Schoenfeld D. Randomized, phase II trial of arimoclomol in rapidly progressive SOD1 ALS. Late-breaking session platform presentation at the 27th International Symposium on ALS/MND, Dublin, Ireland, Dec 7-9, 2016.

Gronka S, Walker M, Wuu J, Stanislaw C, Fanos J, Atassi N, Jaffa M, Andersen P, Cudkowicz M, Benatar M (presenter). Telemedicine to facilitate ALS research. Platform presentation at the 21st International Symposium on ALS/MND, Orlando, FL, Dec 11-13, 2010.

Gronka S, Wuu J, Usher S, Polak M, Benatar M (presenter). Tackling the challenges of ALS from a familial perspective. Platform presentation at the 20th International Symposium on ALS/MND, Berlin, Germany, Dec 4-10, 2009.

Benatar M (invited speaker). Tackling the Challenges of ALS: A Familial Perspective. 2009 William L. Halseth ALS Visiting Lectureship. University of Colorado School of Medicine, Aurora, CO, February 2010.

Benatar M (invited speaker). Randomized Placebo-Controlled Trial of Arimoclomol in SOD1 Positive Familial ALS. ALS Association Drug Discovery Symposium. Seattle, WA, May 2009.

Benatar M (invited speaker). Phase II/III Randomized Placebo-Controlled Trial of Arimoclomol in SOD1 Positive Familial ALS. Packard Center 9th Annual Meeting. Baltimore, MD, April 2009.

Benatar M (invited speaker). Predictive, Preventive and Therapeutic Studies in Familial ALS. ALS Association Annual Leadership Forum. Orange County, CA, January 2008.